Objective: To address this gap, we conducted a pre-registered meta-analysis to synthesize findings from rigorously designed randomized controlled trials (i.e., low attrition, comparable baseline ...

Many systematic reviews contain problematic randomised controlled trials (RCTs). These are studies with false data or results, which could be caused by research misconduct (such as data fabrication) ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

The protocol of this systematic review has been submitted for registration in the PROSPERO databa se, an international prospective register for sys tematic reviews, with ID number CRD420261283257.

As a public health practitioner, you are considering how public health interventions might encourage individuals and families to reduce their salt intake to improve blood pressure among local ...

Objectives We estimated the extent of the disparity between statistical significance and clinical importance in published randomised controlled trials (RCTs), and explored factors associated with this ...

A new study in the American Journal of Preventive Medicine reports findings from a randomized controlled trial—the gold standard study design in health research—showing that promoting drinking water ...

STRENGTHS AND LIMITATIONS OF THIS STUDY This is a large-scale, randomised controlled trial comparing personalised cardiac rehabilitation with usual care. The trial utilises an opt-out approach, ...

The FDA is raising the bar for approval of CAR T-cell therapies in oncology. Under plans outlined by the FDA’s biologics chief Vinay Prasad, M.D., the agency will require developers of many CAR-Ts to ...

For traditional approval, CAR T therapies will need to establish superiority over current standard treatments, including already-approved CAR T products. The FDA is eyeing regulatory changes that ...

Objective To compare the duration of mechanical ventilation between preterm infants receiving closed-loop automated oxygen control (CLAC) or manual oxygen control. Design Randomised controlled trial.