Spatial transcriptomics is transforming how scientists see biology—literally—by mapping gene activity in its original location inside tissues. From decoding tumor architecture to charting entire ...

Type 2 diabetes can turn immune cells that help with tissue repair and anti-inflammatory responses into triggers of chronic ...

Fei Chen and Chenlei Hu at the Broad Institute of MIT and Harvard have developed a new imaging-free spatial transcriptomics technology that tracks the diffusion of DNA barcodes between beads in an ...

Cancer tumorigenesis is fundamentally driven by the profound dysregulation of gene regulatory networks (GRNs) and complex epigenetic alterations. With the ...

Microglia are pivotal players in the neuroinflammatory landscape of Alzheimer’s disease (AD). Accumulating evidence underscores their complex role in ...

Scientists have produced the first comprehensive map of olfactory receptors in the mouse nose, overturning the belief that they were randomly arranged. Using advanced single-cell sequencing and ...

Researchers demonstrate improved spatial mapping technology that enhances transcript detection, identifies key tumor cell ...

Glioblastoma (GBM) is an aggressive type of brain cancer that is known to be very difficult to treat. One reason why this ...

Scientists are realizing just how wrong we've been about how our noses are structured, and how the sense of smell really ...

Transcriptomic phenotyping offers mechanistic insight into adipocyte biology and metabolic disease. A signature of adipocyte ...

Harvard researchers have discovered that smell receptors are organised into precise horizontal stripes within the nose. This ...

A new map shows how smell receptors in the mouse nose are precisely organized into tight bands based on type.