The current path to CAR-T cell therapy is, by any measure, a logistical ordeal. A patient’s immune cells must be drawn out of ...

自身免疫疾病是一组多样化的疾病，其特征是免疫系统错误地攻击身体自身组织，从而导致慢性炎症和组织损伤。 在这些疾病中，自身免疫性肝炎（Autoimmune Hepatitis，AIH）是一种由免疫系统攻击肝细胞所导致的肝脏炎症性疾病。自身免疫性肝炎的临床治疗主要依赖长期大剂量使用免疫抑制剂；然而，长期使用可能会导致严重并发症，例如治疗中断以及可能需要进行肝移植。与有获批靶向疗法的其他自身免疫疾病不同 ...

A breakthrough in CAR-T therapy may allow cancer treatment with a single injection, cutting costs and making care more available.

In the intricate regulation of inflammation, metabolic reprogramming and posttranslational modification (PTM) have emerged as pivotal players, offering new avenues for understanding the fine-tuned ...

The powerful gene-editing technique CRISPR–Cas9 might offer a way to make safer, more effective cancer-fighting immune cells ...

Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...

Researchers in Japan pioneered reprogrammed cells 20 years ago. Now the country has given the first-ever authorizations to manufacture and sell medical products based on the technology.

In order to reprogram readily available cells into specific immune cells that fight various diseases, one must know the “recipe” for the transformation. Researchers at Lund University have now created ...

Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study. The findings ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...

According to a team of researchers at Baylor College of Medicine, Tongji University and collaborating institutions, weaning ...