Meeting the challenges of Huntington’s disease and upper motor neuron diseases like ALS These are exciting times for neurological disease research and the discovery of new therapeutic strategies for ...

Primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases. PLS typically develops slowly, while ALS rapidly affects mobility and can become fatal.

Hyperrelexic, overactive or spastic bladder or bowels occur with spinal cord injury at or above T12. The primary characteristic of this type of injury is increased organ spasms. The UMN bladder may ...

ALS progressively destroys the motor neurons that control voluntary muscles. Upper motor neurons, located in the brain, send messages to lower motor neurons in the spinal cord and from there to ...

Primary lateral sclerosis (PLS) is a rare neurological disorder. It may take several years for a doctor to diagnose PLS. While there’s no cure, treatments can help improve quality of life. Primary ...

Primary lateral sclerosis (PLS) is a rare neurological disorder that affects the motor neurons in the brain and spinal cord, which control movement. It is a form of motor neuron disease (MND). PLS ...

Progressive muscular atrophy (PMA) is a rare adult-onset motor neuron disease. Although there’s no cure, treatments may slow down nerve damage and reduce symptoms. Progressive muscular atrophy (PMA) ...

Motor neurons are some of the largest cells in the human body. In particular, upper neurons—extending from the cerebral cortex to the brain stem or spinal cord—average 60μm in diameter. 3,4 These ...