Houston Methodist scientists have uncovered an unexpected side of a protein best known for its link to brain diseases. The ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

A new study in fruit flies describes how an animal's gut reacts differently to beneficial microbes versus harmful pathogens. A pathway known for repairing damaged genetic material, called the ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

Deep beneath the shifting sea ice of the Arctic Ocean, a massive marine mammal moves slowly through waters that remain near ...

Olaparib in Patients With Solid Tumors With ATM Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study High levels of DNA replication stress and defects in the ...

A new study in fruit flies describes how an animal’s gut reacts differently to beneficial microbes versus harmful pathogens. A pathway known for repairing damaged genetic material, called the ...

Mutational signatures etched into the cells' genome by an anti-cancer drug called temozolomide (TMZ) uncover an Achilles' heel for TMZ chemotherapy resistance, according to new research. In spite of ...

Spread the loveIn a groundbreaking study published on March 15, 2026, researchers from Houston Methodist have unveiled a crucial protein associated with amyotrophic lateral sclerosis (ALS) and ...