DNA甲基化是真核基因组最经典的表观遗传标记之一。过去几十年里，5-甲基胞嘧啶（5mC）几乎等同于“真核DNA甲基化”；而N 6-甲基腺嘌呤（6mA）则常被认为是原核修饰。随着更灵敏的检测与关键催化酶的发现，尤其在纤毛虫、绿藻、部分真菌等单细胞真核生物中，6mA呈现出稳定分布并与具体的生物功能关联，一个更核心的问题随之浮现：5mC与6mA是两条不同调控通路，还是在不同物种中“用不同化学语言讲同一套 ...

△ 表观遗传标记作为环境压力的“哨兵”，灵敏度极高，在海洋生物遭遇海水升温、缺氧或污染等胁迫后的数小时内，其体内的DNA甲基化 （DNA methylation）等分子开关就会迅速发生动态调整，比传统生化指标更早发出预警。

DNA methylation in bacteria, primarily involving the addition of methyl groups to adenine or cytosine residues, constitutes a pivotal epigenetic mechanism that modulates gene expression without ...

长期以来，科学家主要依靠观察物种数量减少、群落结构崩溃、或者生物体出现明显的病理特征，来评估环境质量是不是健康。但，这些宏观层面的信号往往会带有严重的滞后性。当人们发现海床上的贝类大量死亡、或是珊瑚礁变白时，往往悔之晚矣——生态系统的损伤通常已经到了难以挽回的地步。

Cardiovascular disease remains the leading cause of mortality worldwide, necessitating deeper insights into its molecular underpinnings beyond genetic predisposition. Epigenetic modifications, ...

Cancer biology increasingly recognizes that cancer stem cells (CSCs) represent a critical subpopulation within tumors, marked by their self-renewal, ...

The race for early cancer detection is one that physicians have been running for millennia. In one of humanity’s oldest surviving medical texts, the ancient Egyptian physician Imhotep described 46 ...

MyOme, a leader in clinical whole-genome analysis, announced an advancement in rare disease diagnostics at the American College of Medical Genetics and Genomics (ACMG) Annual Meeting. By integrating ...

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