Defects in endosomal sorting have been implicated in Alzheimer’s disease. Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized primarily by lipid ...

Researchers at Brown University and the Marine Biological Laboratory at Woods Hole, Mass., have found a physical connection between the herpes simplex virus and amyloid precursor protein, a protein ...

Alzheimer’s disease can be either sporadic or familial, with common mutations found in amyloid precursor protein (APP) and presenilin genes. The condition can be further classified based by the age of ...

(A, B) ALP staining and activity detection were performed after treating cells with APPswe or BMP2 for 5 days or 7 days. (C, D) ARS staining and semiquantitative analysis were used to detect calcium ...

Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive memory loss and a significant decline in mental functions. Past studies have shown that people with AD exhibit a buildup ...

Share on Pinterest New research looks into the role of amyloid-beta in developing Alzheimer’s. Westend61/Getty Images A main theory behind the cause of Alzheimer’s disease is the build-up of the ...

Watching the Alzheimer’s research world from the outside over the past two years has felt like a car ride over an unpaved mountain road without a seatbelt. In 2021, the US Food and Drug Administration ...

The amyloid protein conformation, a structure that propagates as insoluble fibrils of aggregated β-strand-containing peptides, is a common feature of many neurodegenerative diseases. In Alzheimer, ...

A new study published in the journal JAMA Neurology in April 2020 seems to indicate that higher brain amyloid levels represent early Alzheimer's disease (AD). Amyloid-beta is a significant biomarker ...

Beta-amyloid plaques are considered a hallmark of Alzheimer’s disease, but they’re not the sole cause of the disease and its symptoms. Alzheimer’s is a complicated disease that experts are still ...